EurOPDX consortium
About Objectives Organisation Members Projects Publications
EurOPDX research infrastructure
About Objectives Partners Publications Public Outreach Trans-national Access
Standards PDX Collection News & Events

ABOUT

Patient-derived tumour xenografts (PDX) are now widely embraced by the scientific community as important preclinical tools for cancer biomarker discovery and drug development. However, they are costly and time-consuming to develop. As such, data sharing and collaboration has been essential to the growth of this research field but is still limited by a lack of central guidance and suitable infrastructures

The EurOPDX Consortium teamed up with other key academic and SME partners in a four-year project funded by the European Union’s Horizon 2020 research and innovation programme under the topic “Integrating Activities for Starting Communities”. The EDIReX project was built on the experience and successes of the Consortium, offering a cutting-edge, and much needed, EurOPDX Research Infrastructure for PDX research. The Research Infrastructure is currently part of the canSERV project (GA number 101058620).

EDIReX stands for “EurOPDX Distributed Infrastructure for Research on patient-derived cancer Xenografts” and aimed to improve cancer drug development success rates through the enablement of collaborative PDX research. We indeed developed a user-friendly public repository to facilitate access to the +1500 PDX models from over 30 different cancer types currently curated by the EurOPDX Consortium. To enable effective PDX resource sharing, the project also developed common standards and procedures for PDX biobanking, quality control, and in vivo studies, and offered training in this area. These activities enabled the effective provision of free Trans-National Access (TA) to PDX resources and expertise for academic and industrial cancer researchers from Europe and Worldwide.

Taking advantage of this deep knowledge and excellent strengths, the EurOPDX RI, is now part of canSERV – Cutting Edge Cancer Research Services Across Europe.

The canSERV project provides cutting-edge and customised research services to the cancer research community EU wide, enable innovative R&D projects and foster precision medicine for patient’s benefit across Europe.