Wondering what's up with EurOPDX? Presentation of our EDIReX EU project at next AACR meeting!
April 6, 2018

Wondering what's up with EurOPDX? Presentation of our EDIReX EU project at next AACR meeting!

You may be wondering what we have been working at the past few months, as we have been quite silent at least on the website. Well, if you have the chance to attend the AACR meeting this year (April 14-18 in Chicago, Illinois USA), you will get a chance to know more about it.

Prof. Enzo Medico (University of Torino, Candiolo Cancer Institute - IRCCS, Torino, Italy) will indeed have a short talk during the Session on "Patient-Derived Models of Cancer: Present and Future" held on Sunday April 15, 2018 3:00 PM - 5:00 PM.

The presentation entitled "The EurOPDX EDIReX project: Towards a European research infrastructure on patient-derived cancer models" (Abstract #985, 3:05 PM - 3:20 PM) will get you introduced to our EDIReX project, which just started on February 1 this year, funded by the European Union's Horizon 2020 research and innovation programme (Grant #731105). During this four-year project, we will aim at establishing a cutting-edge European infrastructure offering Trans-national Access to PDX resources to academic and industrial cancer researchers, including the distribution of cryopreserved samples to third parties, the structured biobanking of user-developed models, and the performance of drug efficacy studies. This will imply in particular the set-up of the EurOPDX public repository of models, and further work on establishing standards in the field.

The EDIReX project will be developed in parallel to the additional research activities of the EurOPDX Consortium. Full information will be available within a few months on the EurOPDX website, please come back to know everything about it!
 

EurOPDX members awarded ITN grant to train a new generation of brain cancer researchers
October 9, 2017

EurOPDX members awarded ITN grant to train a new generation of brain cancer researchers

Glioblastoma (GBM), an aggressive and devastating form of brain tumour, will be the focus of the new four-year project GLIOTRAIN just awarded a 3.9 million euros grant from the European Commission’s Horizon 2020 Marie Sklodowska-Curie Innovative Training Network (ITN) initiative. The project, co-ordinated by EurOPDX member Prof. Annette Byrne of the Royal College of Surgeons in Ireland (RCSI) will address the urgent need to identify new treatments for GBM, whilst also aiming to unravel disease resistance mechanisms through state-of-the-art genomics and systems medicine approaches.
Taking a multi-pronged approach, GLIOTRAIN will foster the next generation of young scientists, supporting 15 PhD projects in areas including medical oncology, computational biology, and immunotherapy. This multi-sectoral industry-academia collaboration also includes EurOPDX member Prof. Simone Niclou from the Luxembourg Institute of Health (LIH), and will employ advanced PDX models of GBM in its research.
EurOPDX congratulates Prof. Annette Byrne and Simone Niclou and all GLIOTRAIN partners for their success, and eagerly awaits the results of this young and promising network of future brain cancer research leaders.

GLIOTRAIN website: www.gliotrain.eu
 

**SAVE THE DATE** - 2nd EurOPDX Workshop, Weggis, Switzerland on October 1-3, 2018
July 11, 2017

**SAVE THE DATE** - 2nd EurOPDX Workshop, Weggis, Switzerland on October 1-3, 2018

We are delighted to announce that the second edition of the EurOPDX Workshop will be held on October 1-3, 2018 at the same venue in Weggis, Switzerland.

Although we are keeping a similar size (100-120 attendees), the format may evolve from the first edition to take into account the feedback received last year, as well as new trends and challenges in the field. We want this second workshop to be even more successful than the first one!

A draft programme and list of speakers will be posted on this website during the fall.

If you missed the 1st workshop, please visit its webpage: http://www.europdxworkshop2016.eu/

Hope to see you in Weggis in October 2018!

EC Scientific Conference 'Non-Animal Approaches - The Way Forward': We were there.
December 8, 2016

EC Scientific Conference 'Non-Animal Approaches - The Way Forward': We were there.

We presented a poster at the scientific conference organised by the European Commission in Brussels on December 6-7, 2016 to engage the scientific community and relevant stakeholders in a debate on how to exploit cutting edge advances in biomedical and other research in the development of scientifically valid non-animal approaches (alternatives to animal testing).

The conference brought together people from different countries, scientific disciplines and sectors with expertise in research involving animals and / or non-animal alternative approaches. Through scientific presentations and panel discussions attendees explored the current benefits and limitations of different models, and considered how to improve the quality and predictivity of models used in research, including approaches to accelerate non-animal alternatives.

Very promising alternatives were presented and discussed like organ-on-chip and in silico approaches, but also other ways to comply with the 3Rs (Reduce, Refine, Replace) such as non-invasive imaging. As well as the need for following the ARRIVE guidelines when reporting on in vivo work in order to increase the reproducibility of data, and the need to report on negative results, all to contribute to reducing the number of animals used.

It is crucial to the members of the EurOPDX Consortium to embrasse these issues by designing studies and reporting results in full compliance with the European Directives and the 3Rs. In addition, many of our activities contribute to the 3Rs, such as the development of ex vivo PDX-derived cells for prescreening of models and reduction in the number of animals (if not replacement by avoiding unnecessary in vivo experiments). See previous News on Bruna et al. Cell 2016 article.

Presentations, videos, and the report from the conference are now available at http://ec.europa.eu/environment/chemicals/lab_animals/3r/scientific_conference_non_animal_approaches_en.htm. Our poster is included in the conference content.