Registration for the 2nd EurOPDX Workshop on October 1-3 NOW OPEN!
May 16, 2018

Registration for the 2nd EurOPDX Workshop on October 1-3 NOW OPEN!

Registration for the second edition of the EurOPDX Workshop is now open.

The programme is still in an advanced draft form, but all available information can be found on the workshop website: www.europdxworkshop.eu.

This edition will focus on the following topics:

  • PDX for modelling of metastases
  • Use of ex vivo/in vitro models as pre-testing platforms
  • PDX initiatives
  • Raising standards in the PDX field
  • Clonal evolution & Humanisation of models

We will also take the opportunity of the workshop to present in further details our Horizon 2020 project EDIReX to build a distributed infrastructure for trans-national access to PDX models, and launch the first trans-national access call.

Please follow us on the websites of the Consortium and the Workshop, and on Twitter (@EurOPDX) to get the latest updates! And feel free to send any question to workshop@europdx.eu

We looki forward to seeing you in Weggis, Switzerland in October!

Special focus: the gastric carcinoma PDX collection established at the University of Turin
7th May 2018

Special focus: the gastric carcinoma PDX collection established at the University of Turin

The team of Prof. Silvia Giordano and Dr. Simona Corso at the Department of Oncology, University of Torino/Candiolo Cancer Institute, FPO-IRCCS (Candiolo, Italy) have, over the past few years, established a unique collection of gastric carcinoma PDX models.

Gastric tumour samples and matched normal samples were obtained from patients undergoing surgery in 12 Italian Hospitals. These were used to build a platform of 140 gastric models including 21 derived from tumours of the gastro-oesophageal junction. Targeted sequencing (using a panel of gastric-specific genes defined by the TCGA), gene expression data, MSI and EBV statuses are available for most models and characterisation is being completed. 2D cell lines and organoids are also available for many models.

This gastric PDX platform represents a unique resource to validate biologically relevant targets and assist the clinical development of novel combination strategies for this disease, for which the use of targeted therapies is much less common than in other cancer types.

An article describing the collection is in preparation. Details of the models will soon be included in the EurOPDX repository being established as part of our recent Horizon2020 EU grant to build a EurOPDX distributed infrastructure. The models will also be made available through the PDX Finder portal (www.pdxfinder.org), and available for our upcoming trans-national access funding scheme.

In the meantime, models are already accessible on a collaborative basis by contacting Prof. Silvia Giordano/dr. Simona Corso (silvia.giordano@ircc.it; simona.corso@ircc.it) and the EurOPDX Consortium (contact@europdx.eu). Please submit a short description of your project with your communication.
 

Wondering what's up with EurOPDX? Presentation of our EDIReX EU project at next AACR meeting!
April 6, 2018

Wondering what's up with EurOPDX? Presentation of our EDIReX EU project at next AACR meeting!

You may be wondering what we have been working at the past few months, as we have been quite silent at least on the website. Well, if you have the chance to attend the AACR meeting this year (April 14-18 in Chicago, Illinois USA), you will get a chance to know more about it.

Prof. Enzo Medico (University of Torino, Candiolo Cancer Institute - IRCCS, Torino, Italy) will indeed have a short talk during the Session on "Patient-Derived Models of Cancer: Present and Future" held on Sunday April 15, 2018 3:00 PM - 5:00 PM.

The presentation entitled "The EurOPDX EDIReX project: Towards a European research infrastructure on patient-derived cancer models" (Abstract #985, 3:05 PM - 3:20 PM) will get you introduced to our EDIReX project, which just started on February 1 this year, funded by the European Union's Horizon 2020 research and innovation programme (Grant #731105). During this four-year project, we will aim at establishing a cutting-edge European infrastructure offering Trans-national Access to PDX resources to academic and industrial cancer researchers, including the distribution of cryopreserved samples to third parties, the structured biobanking of user-developed models, and the performance of drug efficacy studies. This will imply in particular the set-up of the EurOPDX public repository of models, and further work on establishing standards in the field.

The EDIReX project will be developed in parallel to the additional research activities of the EurOPDX Consortium. Full information will be available within a few months on the EurOPDX website, please come back to know everything about it!
 

EurOPDX members awarded ITN grant to train a new generation of brain cancer researchers
October 9, 2017

EurOPDX members awarded ITN grant to train a new generation of brain cancer researchers

Glioblastoma (GBM), an aggressive and devastating form of brain tumour, will be the focus of the new four-year project GLIOTRAIN just awarded a 3.9 million euros grant from the European Commission’s Horizon 2020 Marie Sklodowska-Curie Innovative Training Network (ITN) initiative. The project, co-ordinated by EurOPDX member Prof. Annette Byrne of the Royal College of Surgeons in Ireland (RCSI) will address the urgent need to identify new treatments for GBM, whilst also aiming to unravel disease resistance mechanisms through state-of-the-art genomics and systems medicine approaches.
Taking a multi-pronged approach, GLIOTRAIN will foster the next generation of young scientists, supporting 15 PhD projects in areas including medical oncology, computational biology, and immunotherapy. This multi-sectoral industry-academia collaboration also includes EurOPDX member Prof. Simone Niclou from the Luxembourg Institute of Health (LIH), and will employ advanced PDX models of GBM in its research.
EurOPDX congratulates Prof. Annette Byrne and Simone Niclou and all GLIOTRAIN partners for their success, and eagerly awaits the results of this young and promising network of future brain cancer research leaders.

GLIOTRAIN website: www.gliotrain.eu