Registration for the 2nd EurOPDX Workshop on October 1-3 NOW OPEN!
May 16, 2018

Registration for the 2nd EurOPDX Workshop on October 1-3 NOW OPEN!

Registration for the second edition of the EurOPDX Workshop is now open.

The programme is still in an advanced draft form, but all available information can be found on the workshop website: www.europdxworkshop.eu.

This edition will focus on the following topics:

  • PDX for modelling of metastases
  • Use of ex vivo/in vitro models as pre-testing platforms
  • PDX initiatives
  • Raising standards in the PDX field
  • Clonal evolution & Humanisation of models

We will also take the opportunity of the workshop to present in further details our Horizon 2020 project EDIReX to build a distributed infrastructure for trans-national access to PDX models, and launch the first trans-national access call.

Please follow us on the websites of the Consortium and the Workshop, and on Twitter (@EurOPDX) to get the latest updates! And feel free to send any question to workshop@europdx.eu

We looki forward to seeing you in Weggis, Switzerland in October!

Special focus: the gastric carcinoma PDX collection established at the University of Turin
7th May 2018

Special focus: the gastric carcinoma PDX collection established at the University of Turin

The team of Prof. Silvia Giordano and Dr. Simona Corso at the Department of Oncology, University of Torino/Candiolo Cancer Institute, FPO-IRCCS (Candiolo, Italy) have, over the past few years, established a unique collection of gastric carcinoma PDX models.

Gastric tumour samples and matched normal samples were obtained from patients undergoing surgery in 12 Italian Hospitals. These were used to build a platform of 140 gastric models including 21 derived from tumours of the gastro-oesophageal junction. Targeted sequencing (using a panel of gastric-specific genes defined by the TCGA), gene expression data, MSI and EBV statuses are available for most models and characterisation is being completed. 2D cell lines and organoids are also available for many models.

This gastric PDX platform represents a unique resource to validate biologically relevant targets and assist the clinical development of novel combination strategies for this disease, for which the use of targeted therapies is much less common than in other cancer types.

An article describing the collection is in preparation. Details of the models will soon be included in the EurOPDX repository being established as part of our recent Horizon2020 EU grant to build a EurOPDX distributed infrastructure. The models will also be made available through the PDX Finder portal (www.pdxfinder.org), and available for our upcoming trans-national access funding scheme.

In the meantime, models are already accessible on a collaborative basis by contacting Prof. Silvia Giordano/dr. Simona Corso (silvia.giordano@ircc.it; simona.corso@ircc.it) and the EurOPDX Consortium (contact@europdx.eu). Please submit a short description of your project with your communication.
 

Introducing EDIReX: a 5 million EUR infrastructure H2020 project for access to PDX models
April 20, 2018

Introducing EDIReX: a 5 million EUR infrastructure H2020 project for access to PDX models

EDIReX, a four-year project funded as part of the EU Horizon2020 Research and Innovation Program (grant agreement no #731105), kicked-off earlier this year and was introduced by project coordinator Prof. Enzo Medico at the 2018 AACR annual meeting in Chicago.

EDIReX stands for “EurOPDX Distributed Infrastructure for Research on patient-derived cancer Xenografts”. It will offer a cutting-edge distributed research infrastructure comprised of 6 nodes, which will provide free transnational access to PDX resources for academic and industrial cancer researchers. Infrastructure services will include distribution of cryopreserved samples, biobanking of user-developed models, and execution of drug efficacy studies. Built on the successes of the EurOPDX Consortium over the past five years, bringing together a shared collection of over 1500 PDX models, EDIReX comprises 19 partner institutions spanning 13 European countries, and aims to extend the utility of established PDX models as preclinical tools for cancer target and biomarker discovery.

The project and transnational access opportunities will be publicised further in the coming months on this website, and through EurOPDX social media channels; Twitter, LinkedIn, and ResearchGate. Further details can be found on the CORDIS website of the European Commission.
 

Wondering what's up with EurOPDX? Presentation of our EDIReX EU project at next AACR meeting!
April 6, 2018

Wondering what's up with EurOPDX? Presentation of our EDIReX EU project at next AACR meeting!

You may be wondering what we have been working at the past few months, as we have been quite silent at least on the website. Well, if you have the chance to attend the AACR meeting this year (April 14-18 in Chicago, Illinois USA), you will get a chance to know more about it.

Prof. Enzo Medico (University of Torino, Candiolo Cancer Institute - IRCCS, Torino, Italy) will indeed have a short talk during the Session on "Patient-Derived Models of Cancer: Present and Future" held on Sunday April 15, 2018 3:00 PM - 5:00 PM.

The presentation entitled "The EurOPDX EDIReX project: Towards a European research infrastructure on patient-derived cancer models" (Abstract #985, 3:05 PM - 3:20 PM) will get you introduced to our EDIReX project, which just started on February 1 this year, funded by the European Union's Horizon 2020 research and innovation programme (Grant #731105). During this four-year project, we will aim at establishing a cutting-edge European infrastructure offering Trans-national Access to PDX resources to academic and industrial cancer researchers, including the distribution of cryopreserved samples to third parties, the structured biobanking of user-developed models, and the performance of drug efficacy studies. This will imply in particular the set-up of the EurOPDX public repository of models, and further work on establishing standards in the field.

The EDIReX project will be developed in parallel to the additional research activities of the EurOPDX Consortium. Full information will be available within a few months on the EurOPDX website, please come back to know everything about it!